Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons
نویسندگان
چکیده
منابع مشابه
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.
Cell surface proteolysis is essential for communication between cells and results in the shedding of membrane-protein ectodomains. However, physiological substrates of the contributing proteases are largely unknown. We developed the secretome protein enrichment with click sugars (SPECS) method, which allows proteome-wide identification of shedding substrates and secreted proteins from primary c...
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Proteins of the Seizure protein 6 (Sez6) family are abundant in neurons and are localized to the somatodendritic compartment of these highly polarised cells (Gunnersen et al., 2007; Miyazaki et al., 2006). Two recent studies (Kuhn et al., 2012; Pigoni et al., 2016) highlight the important role of the Alzheimer’s disease (AD)-linked aspartyl-protease β-site amyloid precursor protein (APP) cleavi...
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DNA pooling in combination with high-throughput sequencing was done as a part of the Sequenom-Genefinder project. In the pilot study, we tested 83,715 single nucleotide polymorphisms (SNP), located primarily in gene-based regions, to identify polymorphic susceptibility variants for lung cancer. For this pilot study, 369 male cases and 287 controls of both sexes (white Europeans of Southern Germ...
متن کاملBeta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6
BACKGROUND Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a promising drug target for the treatment of Alzheimer's disease. Prolonged BACE1 inhibition interferes with structural and functional synaptic plasticity in mice, most likely by altering the metabolism of BACE1 substrates. Seizure protein 6 (SEZ6) is predominantly cleaved by BACE1, and Sez6 knockout mice share some phe...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2016
ISSN: 1750-1326
DOI: 10.1186/s13024-016-0134-z